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KMID : 1123920150290010046
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Korean Journal of Oriental Physiology and Pathology
2015 Volume.29 No. 1 p.46 ~ p.50
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Inhibitory Effects of Portulaca Oleracea Ethanol Extract and Glechoma Hederacea Ethanol Extract on the Periodontitis
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Park Young-Mi
Lee Young-Rae
Park Sang-Hoon
Lee Bong-Gun
Park Yeon-Ju
Oh Hong-Geun
Moon Dae-In
Son Min-Woo
Kang Yang-Gyu
Kim Ok-Jin
Lee Seok-Ryun
Lee Choong-Hun
Kim Min-Seuk
Lee Hak-Yong
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Abstract
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Both Portulaca oleracea (PO) and Glechoma hederacea (GH) have been used as traditional medicine due to the multiple pharmacological activities. However, the effects of PO and GH in the pathology of periodontitis is still elusive. In this study, we examined anti-microbial activity of PO ethanol extract (POEE) and GH ethanol extract (GHEE) in vitro, and physiological effects of POEE and GHEE on the cell inflammatory responses and the severity of periodontitis were determined using the rat periodontitis model. Our results indicate that POEE and GHEE had no effects on the proliferation of streptococcus mutans and on LPS-mediated inflammatory responses in gingival fibroblast cells. Notably, ingestion of POEE and GHEE resulted in attenuating the severity of periodontitis and population change of immune cells. These data suggests that PO and GH should be considered as candidates for relieving the severity of periondontitis.
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KEYWORD
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Portulaca oleracea, periodontitis, streptococcus mutans
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